The rationale design of functional molecular scaffolds with predictable and tunable physical, chemical and biological properties is a key activity of LabFact. Our partners have experience in engineering scaffolds for a diverse range of applications, including as chemical probes, modulators of biological activity, building blocks, rule of three fragments, new functional materials and new catalysts, amongst others.
Key Abstracts
The amyloid architecture provides a scaffold for enzyme-like catalysts
Late Stage C-H Activation of a Privileged Scaffold. Synthesis of a Library of Benzodiazepines
Microwave-Assisted Synthesis of 3-Aminobenzo[b]thiophene Scaffolds for the Preparation of Kinase Inhibitors
A Poised Fragment Library Enables Rapid Synthetic Expansion Yielding the First Reported Inhibitors of PHIP(2), an Atypical Bromodomain
Members Involved
